Our Research Projects
Full list of JDCBS Research Projects
Specific studies which have been made possible by the existence of the Juvenile Dermatomyositis Cohort Biomarker Study & Repository, include:
Ongoing Projects
- S. Tansley – Establishing early markers of severe disease in JDM
- L. Rider – Risk and Protective Factors for Calcinosis in Juvenile Dermatomysitis
- L. Wedderburn – Integration of clinical and multi-omics data in the High-5 project (extension SY.1.2013)
- R. Ebrahim – Comparing the use of 1g/kg Intravenous Immunoglobulins (IVIg) dose against the standard dose of 2g/kg in patients with Juvenile Dermatomyositis (JDM): A retrospective cohort study
- C. T. Deakin – Transcriptional profiles of human endogenous retroviral elements in children adolescents with rheumatic diseases
- M. Leandro – Use of B cell depletion therapy based on rituximab in the treatment of refractory juvenile dermatomyositis in the JDCBS cohort study
- M. Wilkinson – A pilot study to investigate spatial transcriptomics of JDM muscles
- C. Papadopoulou – Sleep disturbances and fatigue in children with Juvenile Dermatomyositis (JDM); a pilot study
- M. Wilkinson – To develop and share a JDM single-cell cross-tissue spatially resolved atlas to accelerate precision medicine through partnership with an international research network and diverse patient communities
- L. McCann – MYOSCOPE: Bringing a visual measure of disease activity into clinical practice to help children with dermatomyositis
- J. Chung – Evaluation of treatment efficacy and long-term outcomes among children diagnosed with dermatomyositis or polymyostis.
- S. Velkdkamp – Integrative Analysis of IFN dysregulation and mitochondrial dysfunction on protein and transcriptomic level in Juvenile Dermatomyositis (JDM): Toward Predictive Treatment Strategies
- L. Rider – Standardized Interoperable Data Collection for Myositis Research
- C. Papadopoulou – IL18 as a biomarker of Interstitial Lung disease associated with juvenile idiopathic inflammatory myopathies
- R. Najjar – Expression of transposable elements in JDM
- C. Papadopoulou – Severity Scores of Interstitial Lung Disease on Computed Tomography Thorax in Patients with Juvenile Dermatomyositis and Correlation with Biochemical and Clinical Markers.
Completed Projects
- R. Hamilton – The GOSH DRE
- R. Hamilton – Inclusion of the JDCBS in the Health Data Research – UK (HDRUK) database
- N. Groot – Immune response after Human Papillomavirus vaccination in patients with autoimmune disease
- E. Moraitis & R. Marques – Effectiveness of Intravenous Cyclophosphamide and IVIG in the Treatment of Juvenile Dermatomyositis
- L. Wedderburn – Immunological characterisation of the infiltrate in JDM muscle
- L. Wedderburn – Tracking of lymphocyte changes before or after flare of active disease
- L. Wedderburn – Analysis of MHC Class 1 expression in an animal model of myositis
- L. Wedderburn – Recognition of MHC Class 1 molecules on muscle cells by lymphocytes (CD8 T cells or NK cells)
- K. Nistala – The role of muscle ultrasound in juvenile dermatomyositis
- L. Wedderburn – Investigation of alterations of MRP8/14 proteins in juvenile dermatomyositis
- J. Davidson – Autoantibodies in Juvenile Dermatomyositis, Scleroderma and overlap syndromes
- H. Ireland – Do functional gene variants in anti-inflammatory pathways alter the course of disease and allow greater inflammatory response?
- P. Brogan – Fetuin-A and calcinosis in Juvenile dermatomyositis
- L. Wedderburn – Genotyping analysis in JDM for phenotype: genotype correlation
- AV. Ramanan – Is there evidence of maternal microchimerism in muscle biopsies from children with Juvenile Dermatomyositis?
- L. Wedderburn – Extension for Genotyping analysis in JDM for phenotype: genotype correlation
- L. Wedderburn – Genome wide association study of the idiopathic inflammatory myopathies
- P. Brogan, C. Papadopoulou – The Vasculopathy of JDM
- S.Maillard – To assess fatigue in children with Juvenile Dermatomyositis
- N. Martin – A survey of current practice in Juvenile Dermatomyositis throughout the UK and Ireland
- C. Pilkington – Development of Classification Criteria for the Idiopathic Inflammatory Myopathies and their Major Subgroups
- C. Pilkington – Five year single blind, phase III effectiveness randomised actively controlled clinical trial in new onset juvenile dermatomyositis: prednisolone versus prednisolone plus cyclosporinA versus prednisolone plus methotrexate
- C. Pilkington – IMACS Outcomes Repository
- E. Boulter – Effectiveness of anti-TNF alpha agents in the treatment of refractory JDM
- Y. Vercoulen – The role of regulatory cells in the pathogenesis of active JDM
- K. Nistala – Regulatory and effector B cell function in childhood rheumatic disease
- S. Brady – Inclusion body myositis: The ‘Alzheimer’s disease of muscle’ – a diagnostic challenge
- L. McCann – Proposal for the development of an international minimal data collection for JDM
- I. Lundberg – International Myositis Classification Criteria Project
- G. Varnier – Juvenile Dermatomyositis Cohort Biomarker Study and Repository (UK and Ireland)
- K. Nistala, D. Eleftheriou – Proteasome dysfunction in the pathogenesis of juvenile dermatomyositis.
- B. Almeida – A project to investigate 3 skin scoring tools in children with Juvenile Dermatomyositis
- J. Griffin – The relationship between foot position and muscle strength in the child with Juvenile dermatomyositis.
- S. Yasin, C.Deakin – Integrative genetic, immunological and clinical subphenotyping in JDM
- M. de Iorio – Bayesian Modelling of Disease Progression in Juvenile Dermatomyositis (JDM)
- G. Varnier – A therapeutic approach and outcome of children with Dermatomyositis followed in tertiary care European Paediatric Rheumatology Centre
- A. v. Royen-Kerkhof – Validation study of biomarkers in JDM
- A. Offiah – Optimisation of a novel magnetic resonance imaging-based scoring system for assessing disease activity in children with juvenile dermatomyositis
- B. Almeida – Clinically Inactive Disease in Juvenile Dermatomyositis – a proposed revision to the PRINTO criteria
- C. Boros – Assessment of Long Term Outcomes in Juvenile Inflammatory Myopathies
- S. Rasul – Age-related differences in Anti-Mi2 positive Juvenile Dermatomyositis
- S. Rosina – Development and validation of a composite disease activity score for juvenile dermatomyositis (Juvenile Dermatomyositis Activity Index – JDMAI)
- M. Wilkinson – Investigating novel pathways in B cell mediated autoimmunity in juvenile dermatomyositis
- S. Rothwell – Identification of new MHC genes associated with myositis autoantibodies
- O. Boyer – Dermatomyositis TIF1g IgG2 study
- M. Wilkinson – A survey to understand the feelings towards and impact of COVID-19 on the households of JDM patients from a parent or guardian perspective
- G. Kassiotis – Pre-existing and de novo antibody responses to SARS-CoV-2 in healthy volunteers and paediatric rheumatology patients
Office Location
Juvenile Dermatomyositis Cohort Biomarker Study & Repository (JDCBS)
UCL Great Ormond Street
Institute of Child Health
6th Floor
30 Guilford Street
London, WC1N 1EH